Brain Byte

Interstitial Cells of Cajal

  • Published13 Nov 2020
  • Author Calli McMurray
  • Source BrainFacts/SfN

The gut’s pacemaker cells, interstitial cells of Cajal, produce slow electrical waves to keep food moving through the digestive tract.

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 Interstitial Cells of Cajal Brain byte
Design by A. Tong

Design by Adrienne Tong.

Image "Physiology, Injury, and Recovery of Interstitial Cells of Cajal" by Huizinga et al. Gastroenterology, 2009.

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BrainFacts/SfN

Huizinga, J. D., Chen, J., Mikkelsen, H. B., Wang, X., Parsons, S. P., & Zhu, Y. F. (2013). Interstitial cells of Cajal, from structure to function. Frontiers in Neuroscience, 7. doi:10.3389/fnins.2013.00043 

Al-Shboul, O. A. (2013). The Importance of Interstitial Cells of Cajal in the Gastrointestinal Tract. Saudi J Gastroenterol, 19(1), 3-15. doi:10.4103/1319-3767.105909

Huizinga, J. D., Zarate, N., & Farrugia, G. (2009). Physiology, Injury, and Recovery of Interstitial Cells of Cajal: Basic and Clinical Science. Gastroenterology, 137(5), 1548-1556. doi:10.1053/j.gastro.2009.09.023

Klein, S., Seidler, B., Kettenberger, A., Sibaev, A., Rohn, M., Feil, R., . . . Saur, D. (2013). Interstitial cells of Cajal integrate excitatory and inhibitory neurotransmission with intestinal slow-wave activity. Nature Communications, 4(1). doi:10.1038/ncomms2626

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