Snapshots in Neuroscience: Cerebellar Cortex

This image has been selected to showcase the art that neuroscience research can create.

As described by Dr. Gebril and colleagues: The image shows part of the juvenile cerebellar cortex of a mouse at postnatal day 21. This is a triple immunofluorescence staining for glial fibrillary acidic protein (GFAP, green), calbindin (blue) and adenosine kinase (ADK, red).

This image was taken within the context to analyze the expression of ADK during cerebellar development. ADK, the main regulator of adenosine, undergoes coordinated expression changes during brain development and its isoform ADK-L, expressed in the cell nucleus, plays a role in neurogenesis and cell proliferation.

Here we show that ADK expression is associated with the proliferation of young neurons and with development of the cerebellum in mice.

This image is a maximum projection of images captured at multiple focal planes (z-stack/ 20x objective) using a Leica DM4B microscope fitted with a StereoInvestigator system and a monochrome digital camera.

Read the full article:

Developmental Role of Adenosine Kinase in the Cerebellum
Hoda Gebril, Amir Wahba, Xiaofeng Zhou, Tho Lai, Enmar Alharfoush, Emanuel DiCicco-Bloom, and Detlev Boison