Disorders of the Nervous System

Authors demonstrate that long-distance axon regeneration can drive recovery of respiratory function following cervical spinal cord injury in rats.
By Lydia E. Strattan
February 27, 2020

Authors demonstrate that long-distance axon regeneration can drive recovery of respiratory function following cervical spinal cord injury in rats.

Photo of Munjal Acharya, PhD, Assistant Professor, University of California, Irvine and Charles Limoli, PhD, Professor, Radiation Oncology, University of California, Irvine.
By Rosalind S.E. Carney, DPhil
December 12, 2019

Munjal Acharya and Charles Limoli discuss new concerns that radiation-induced neurocognitive risks could comprise astronaut safety during NASA’s intended mission to Mars.

Authors show that key features of the microglial activation pattern observed after status epilepticus may not be related to the epileptogenic process.
By Atehsa Sahagun
September 5, 2019

Authors show that key features of the microglial activation pattern observed after status epilepticus may not be related to the epileptogenic process.

Authors show that blocking endogenous Bone Morphogenetic Protein 4 signaling via a selective pharmacological approach promotes oligodendroglial differentiation and increases the rate of remyelination after a central demyelinating insult in vivo.
By Claudia Lopez-Lloreda
June 27, 2019

Authors show that blocking endogenous Bone Morphogenetic Protein 4 signaling via a selective pharmacological approach promotes oligodendroglial differentiation and increases the rate of remyelination after a central demyelinating insult in vivo.

Authors provide the first functional description of the emergence of neocortical fast ripples in hippocampal epilepsy and show that cross-frequency coupling might be a fundamental mechanism underlying the spreading of epileptic activity.
By William Stacey, MD, PhD
June 13, 2019

Authors provide the first functional description of the emergence of neocortical fast ripples in hippocampal epilepsy and show that cross-frequency coupling might be a fundamental mechanism underlying the spreading of epileptic activity.

Figure 1. High-speed confocal imaging and LFP recording in the forebrain of GCaMP-expressing zebrafish larvae. (A) Timeline of confocal imaging and LFP recording relative to immobilization of larvae in agar and exposure to convulsant drugs. High-speed confocal recordings were obtained ∼40 minutes after drug exposure, with 5× and 20× objectives used for whole-brain and single neuron imaging, respectively. (B) Simultaneous high-speed confocal imaging and LFP recording in agar-embedded larvae. (C) Schematic illustration depicting sub-regions of the larval zebrafish brain. (D) Representative 5× image of Tg(neurod1:GCaMP6f) zebrafish at 5–6 days postfertilization. (Adapted from Figure 1 in Liu & Baraban et al., 2019.)
By Rosalind S.E. Carney, DPhil
May 9, 2019

Authors used well-established seizure protocols and fast confocal imaging of genetically encoded calcium indicator-expressing zebrafish to investigate epileptic network properties at brain-wide and single-cell levels.

Authors show that the same stress can elicit divergent morphological effects in astrocytes in the hippocampus versus the amygdala.
By Abha Karki Rajbhandari, PhD
March 28, 2019

Authors show that the same stress can elicit divergent morphological effects in astrocytes in the hippocampus versus the amygdala.

Authors found that experimentally induced stroke causes a secondary wave of brain tissue inflammation that shares some molecular and morphological characteristics with atherosclerosis.
By Matthew Davidson, PhD
February 14, 2019

Authors found that experimentally induced stroke causes a secondary wave of brain tissue inflammation that shares some molecular and morphological characteristics with atherosclerosis.

By Rosalind S.E. Carney, DPhil
October 31, 2018

Authors demonstrate that capsaicin, a TRPV1 agonist, activates a pro-axon growth program, suggesting an approach for enhancing axon regeneration in selective populations of neurons.

Authors functionally defined immediate-early astrocytes (ieAstrocytes) as an in vivo astrocyte population, modulated by S1P signaling, in a mouse model of multiple sclerosis.
By Rosalind S.E. Carney, DPhil
October 15, 2018

Authors functionally defined immediate-early astrocytes (ieAstrocytes) as an in vivo astrocyte population, modulated by S1P signaling, in a mouse model of multiple sclerosis.