Disorders of the Nervous System
Authors show that key features of the microglial activation pattern observed after status epilepticus may not be related to the epileptogenic process.
Authors show that blocking endogenous Bone Morphogenetic Protein 4 signaling via a selective pharmacological approach promotes oligodendroglial differentiation and increases the rate of remyelination after a central demyelinating insult in vivo.
Authors provide the first functional description of the emergence of neocortical fast ripples in hippocampal epilepsy and show that cross-frequency coupling might be a fundamental mechanism underlying the spreading of epileptic activity.
Authors used well-established seizure protocols and fast confocal imaging of genetically encoded calcium indicator-expressing zebrafish to investigate epileptic network properties at brain-wide and single-cell levels.
Authors show that the same stress can elicit divergent morphological effects in astrocytes in the hippocampus versus the amygdala.
Authors found that experimentally induced stroke causes a secondary wave of brain tissue inflammation that shares some molecular and morphological characteristics with atherosclerosis.
Authors demonstrate that capsaicin, a TRPV1 agonist, activates a pro-axon growth program, suggesting an approach for enhancing axon regeneration in selective populations of neurons.
Authors functionally defined immediate-early astrocytes (ieAstrocytes) as an in vivo astrocyte population, modulated by S1P signaling, in a mouse model of multiple sclerosis.