Celebrating 10 Years | 2020

The Society for Neuroscience launched its gold open-access journal in November 2014. As founding Editor-in-Chief Christophe Bernard said in his editorial, “eNeuro at Ten: Just Warming Up,” “eNeuro was designed to serve the community of neuroscientists.”

To celebrate 10 years of eNeuro, throughout the year the blog will highlight findings of some of the most-cited papers published in each year of the journal’s history.

2020

Electrophysiological Frequency Band Ratio Measures Conflate Periodic and Aperiodic Neural Activity
Thomas Donoghue, Julio Dominguez, and Bradley Voytek

Donoghue and colleagues used a combined simulation and EEG approach to challenge the idea that band ratio measures in electrophysiological data can be interpreted as changes in oscillatory power at different bands. They discovered that band ratio estimates are affected by oscillatory power and aperiodic signals of the power spectrum and cautioned neuroscientists to use parameters to dissociate periodic and aperiodic components of power spectra. This study significantly contributed to our understanding of potential issues with traditional spectral analyses.

 

Altered Expression of the m6A Methyltransferase METTL3 in Alzheimer’s Disease
He Huang, Judith Camats-Perna, Rodrigo Medeiros, Victor Anggono, and Jocelyn Widagdo

This study explored a group of genes and proteins involved in learning and memory that had never been investigated in the context of Alzheimer’s disease (AD). Huang et al. assessed brain tissue post-mortem and found diminished hippocampal mRNA expression of a methyltransferase enzyme for N6-methyladenosine (m6A) between AD patients and controls. Insoluble protein levels of this enzyme in the hippocampus positively correlated with levels of insoluble Tau protein in AD patients. These findings moved the needle forward in our understanding of AD by pointing to a new potential cellular mechanism for dysregulation of gene expression associated with AD.