Authors developed the open-source ToneBox tool, which allows both novice and expert behaviorists to automatically test hundreds of mice simultaneously on different behavioral tasks.
Authors examined the reliability of using Cre-induced recombination of one gene to predict recombination in another gene at the single-cell level in adult hippocampal neural stem and progenitor cells.
Authors explored the role of the Bed Nucleus of the Stria Terminalis in the reinstatement and renewal of fear—two forms of fear relapse that are differentially triggered by stress.
Chronic ethanol exposure and withdrawal in rats produce opposing effects on glutamate release in the basolateral amygdala from axons originating in subdivisions of the medial prefrontal cortex, chemogenetic inhibition attenuates the increase in anxiety-like behavior associated with ethanol withdrawal.
Authors demonstrate that ApoE deficiency and the ApoE4 human isoform both impair hippocampal neurogenesis in adult mice and give insight into how ApoE may influence hippocampal-related neurological diseases.
Authors demonstrate that long-distance axon regeneration can drive recovery of respiratory function following cervical spinal cord injury in rats.
An automated analysis approach to reduce the heterogeneity of dendritic spine morphology could enhance reproducibility in neurological disorders with defective synaptic transmission.
Authors targeted the microglia-specific Tmem119 gene to generate two novel mouse models that can be used to visualize and control reporter protein expression in microglia with improved distinction from closely related cell types.
Authors suggest that blue light stimulation is ill-suited to long-term optogenetic experiments, especially those that measure transcription.
This research offers an important contribution to the knowledge of molecular mechanism of worm learning and sensory integration that may be applicable to learning in many organisms.