Authors show that microbiome depletion by antibiotics in rats produces widespread changes in the recruitment of neuronal ensembles that are activated by oxycodone intoxication and withdrawal.
Authors highlight a deficit in motor skill consolidation-dependent synaptic plasticity at motor cortex to dorsal striatum synapses that represents an early biomarker for Huntington’s Disease in mice.
Authors demonstrate that epidermal growth factor receptor antagonism not only blocks morphine tolerance but also restores the effectiveness of opioids against neuropathic pain.
Authors highlight TrkB-dependent molecular pathways as critical for the maturation of inhibitory interneurons and support the hypothesis that loss of BDNF signaling in cortistatin interneurons leads to altered excitatory/inhibitory balance.
Authors developed the open-source ToneBox tool, which allows both novice and expert behaviorists to automatically test hundreds of mice simultaneously on different behavioral tasks.
Authors examined the reliability of using Cre-induced recombination of one gene to predict recombination in another gene at the single-cell level in adult hippocampal neural stem and progenitor cells.
Authors explored the role of the Bed Nucleus of the Stria Terminalis in the reinstatement and renewal of fear—two forms of fear relapse that are differentially triggered by stress.
Chronic ethanol exposure and withdrawal in rats produce opposing effects on glutamate release in the basolateral amygdala from axons originating in subdivisions of the medial prefrontal cortex, chemogenetic inhibition attenuates the increase in anxiety-like behavior associated with ethanol withdrawal.
Authors demonstrate that ApoE deficiency and the ApoE4 human isoform both impair hippocampal neurogenesis in adult mice and give insight into how ApoE may influence hippocampal-related neurological diseases.
Authors demonstrate that long-distance axon regeneration can drive recovery of respiratory function following cervical spinal cord injury in rats.