Novel Tools and Methods

An automated analysis approach to reduce the heterogeneity of dendritic spine morphology could enhance reproducibility in neurological disorders with defective synaptic transmission.
By Juan C Sanchez-Arias, MD, and Simona D Frederiksen, PhD
December 5, 2019

An automated analysis approach to reduce the heterogeneity of dendritic spine morphology could enhance reproducibility in neurological disorders with defective synaptic transmission.

Authors targeted the microglia-specific Tmem119 gene to generate two novel mouse models that can be used to visualize and control reporter protein expression in microglia with improved distinction from closely related cell types
By Dah-eun (Chloe) Chung, PhD
October 31, 2019

Authors targeted the microglia-specific Tmem119 gene to generate two novel mouse models that can be used to visualize and control reporter protein expression in microglia with improved distinction from closely related cell types.

Authors suggest that blue light stimulation is ill-suited to long-term optogenetic experiments, especially those that measure transcription.
By Thiago Arzua
October 23, 2019

Authors suggest that blue light stimulation is ill-suited to long-term optogenetic experiments, especially those that measure transcription.

Authors describes an unexpected effect of in utero electroporation of plasmid DNA on the distribution of microglia within the developing forebrain.
By Orly Reiner
January 24, 2019

Authors describe an unexpected effect of in utero electroporation of plasmid DNA on the distribution of microglia within the developing forebrain.

By Rosalind S.E. Carney, DPhil
September 11, 2018

Authors established a novel, automated live-cell imaging method to identify morphological changes in individual, dying human motor neurons.