Novel Tools and Methods
Authors developed the open-source ToneBox tool, which allows both novice and expert behaviorists to automatically test hundreds of mice simultaneously on different behavioral tasks.
Parley Belsey and Eric Yttri tell the story about how they created a highly customizable, low cost and reproducible open-source behavior training platform for studying motor control, decision-making, and reaching reaction time in rodents.
Neurons responding to medicinal and abused opioids are visualized for the first time in the mouse brain.
An automated analysis approach to reduce the heterogeneity of dendritic spine morphology could enhance reproducibility in neurological disorders with defective synaptic transmission.
Authors targeted the microglia-specific Tmem119 gene to generate two novel mouse models that can be used to visualize and control reporter protein expression in microglia with improved distinction from closely related cell types.
Authors suggest that blue light stimulation is ill-suited to long-term optogenetic experiments, especially those that measure transcription.
Authors describe an unexpected effect of in utero electroporation of plasmid DNA on the distribution of microglia within the developing forebrain.
Authors established a novel, automated live-cell imaging method to identify morphological changes in individual, dying human motor neurons.