Novel Tools and Methods
An automated analysis approach to reduce the heterogeneity of dendritic spine morphology could enhance reproducibility in neurological disorders with defective synaptic transmission.
Authors targeted the microglia-specific Tmem119 gene to generate two novel mouse models that can be used to visualize and control reporter protein expression in microglia with improved distinction from closely related cell types.
Authors suggest that blue light stimulation is ill-suited to long-term optogenetic experiments, especially those that measure transcription.
Authors describe an unexpected effect of in utero electroporation of plasmid DNA on the distribution of microglia within the developing forebrain.
Authors established a novel, automated live-cell imaging method to identify morphological changes in individual, dying human motor neurons.