Novel Tools and Methods
The image shows a clarified, 1-mm-thick sagittal section of whole brain from a transgenic mouse expressing a fluorescent reporter for caspase-3/7 activity.
This image shows a hippocampal neuron with endogenous labelling of the cytoskeleton proteins β-actin and β3 tubulin using CRISPR/Cas9.
This paper offers a valuable comparison to guide neuroscientists in choosing an appropriate spike sorting algorithm.
An image of a wild-type mouse hippocampus expressing Cre-dependent green fluorescent protein.
Learn how and why eNeuro became a venue to publish and share Open-Source Tools and Methods papers.
Tonebox: Automated Tool for Behavioral Analyses and Potential Integration With Other Open Source Methods
Authors developed the open-source ToneBox tool, which allows both novice and expert behaviorists to automatically test hundreds of mice simultaneously on different behavioral tasks.
Parley Belsey and Eric Yttri tell the story about how they created a highly customizable, low cost and reproducible open-source behavior training platform for studying motor control, decision-making, and reaching reaction time in rodents.
Neurons responding to medicinal and abused opioids are visualized for the first time in the mouse brain.
An automated analysis approach to reduce the heterogeneity of dendritic spine morphology could enhance reproducibility in neurological disorders with defective synaptic transmission.
Authors targeted the microglia-specific Tmem119 gene to generate two novel mouse models that can be used to visualize and control reporter protein expression in microglia with improved distinction from closely related cell types.