Celebrating 10 Years | 2017

The Society for Neuroscience launched its gold open-access journal in November 2014. As founding Editor-in-Chief Christophe Bernard said in his editorial, “eNeuro at Ten: Just Warming Up,” “eNeuro was designed to serve the community of neuroscientists.”

To celebrate 10 years of eNeuro, throughout the year the blog will highlight findings of some of the most-cited papers published in each year of the journal’s history.

2017

Aberrant Cortical Activity in Multiple GCaMP6-Expressing Transgenic Mouse Lines
Nicholas A. Steinmetz, Christina Buetfering, Jerome Lecoq, Christian R. Lee, Andrew J. Peters, Elina A. K. Jacobs, Philip Coen, Douglas R. Ollerenshaw, Matthew T. Valley, Saskia E. J. de Vries, Marina Garrett, Jun Zhuang, Peter A. Groblewski, Sahar Manavi, Jesse Miles, Casey White, Eric Lee, Fiona Griffin, Joshua D. Larkin, Kate Roll, Sissy Cross, Thuyanh V. Nguyen, Rachael Larsen, Julie Pendergraft, Tanya Daigle, Bosiljka Tasic, Carol L. Thompson, Jack Waters, Shawn Olsen, David J. Margolis, Hongkui Zeng, Michael Hausser, Matteo Carandini, and Kenneth D. Harris

Transgenic mouselines are important preclinical research tools. Scientists have used them to advance our understanding of the mechanisms of cognition, behavior, and neurological disease. However, they aren’t full proof and insight into their drawbacks is important for more accurate experimental interpretations and conclusions. Steinmetz et al. reported in this paper that multiple transgenic mouselines expressing a frequently used genetically encoded calcium sensor have aberrant electrical activity in cortical neurons. While many neuronal responses and behaviors seemed normal despite these changes, some mice experienced seizures. The findings of this paper stand as an important note of caution for researchers using these transgenic mouselines.

 

Communication between Brain Areas Based on Nested Oscillations
Mathilde Bonnefond, Sabine Kastner, and Ole Jensen

Bonnefond and colleagues delve into the literature in this conceptual paper to bridge together two overarching theories for how brain regions communicate to enable the processing of external and internal information. They used the support of many empirical findings to present their theory that communication is established by phase synchronization of lower frequency oscillations of neural activity, and this provides a temporal reference for information carried by higher-frequency oscillations. The knowledge gaps addressed and the questions introduced in this paper were advancements for the field.