Editor’s Pick: Exploring mechanosensation in marmosets

Understanding somatosensation in humans requires models that closely approximate human neurobiology. This innovative study is the first to characterize mechanically activated currents in trigeminal ganglion neurons from non-human primates. Using a combination of electrophysiology and immunohistochemistry in marmosets, the authors identify distinct neuronal subtypes and link their functional profiles to known molecular markers.

The work stands out for its thorough classification of neuron subtypes and its thoughtful comparison to rodent and cross-species transcriptomic datasets. By establishing foundational knowledge in a translationally relevant model, this paper opens the door for future investigations into the molecular and cellular mechanisms underlying mechanosensation—and ultimately pain—in humans.

— Jennifer Dulin, Reviewing Editor

Read the full article:

Investigating Mechanically Activated Currents from Trigeminal Neurons of Non-Human Primates
Karen A. Lindquist, Jennifer Mecklenburg, Anahit H. Hovhannisyan, Shivani Ruparel, RE-JOIN Consortium Investigators, and Armen N. Akopian