Celebrating 10 Years | 2023

The Society for Neuroscience launched its gold open-access journal in November 2014. As founding Editor-in-Chief Christophe Bernard said in his editorial, “eNeuro at Ten: Just Warming Up,” “eNeuro was designed to serve the community of neuroscientists.”

To celebrate 10 years of eNeuro, throughout the year the blog will highlight findings of some of the most-cited papers published in each year of the journal’s history.

2023

Brain FNDC5/Irisin Expression in Patients and Mouse Models of Major Depression
Ricardo Lima-Filho, Juliana S. Fortuna, Danielle Cozachenco, Alinny R. Isaac, Natalia Lyra e Silva, Alice Saldanha, Luis E. Santos, Sergio T. Ferreira, Mychael V. Lourenco, and Fernanda G. De Felice

In this paper, Lima-Filho and colleagues discovered diminished expression of a gene associated with exercise (FNDC5) in postmortem brain tissue from patients with major depressive disorder and explored the role of FNDC5 in depression-like behaviors in mice. Their findings suggested that FNDC5 is protective against depression-like behaviors and perhaps depression. This recent study is among the first to explore the understudied link between exercise and depression.

 

The Mobility of Neurofilaments in Mature Myelinated Axons of Adult Mice
J. Daniel Fenn, Yinyun Li, Jean-Pierre Julien, Peter Jung, and Anthony Brown

Prior to this study, there was much controversy about the mobility of neurofilaments in adult axons. This paper by Fenn et al. resolved this issue using an ideal experimental system and a computational model. The authors ultimately solidified the idea that a large portion of neurofilaments is indeed motile.