Editor's Pick: Novel Mechanistic Links Between Trophic Factor Deprivation and Sensory Axon Degeneration
Authors identify capsaicin receptor TRPV1 as a key regulator of Ca2+ entry into axoplasm that is required for developmental degeneration modeled by NGF withdrawal from sensory neurons of the dorsal root ganglion in vitro.
Editor's Pick: Plasmid DNA Causes Aberrant Distribution of Microglia Following In Utero Electroporation In Forebrain
Authors describe an unexpected effect of in utero electroporation of plasmid DNA on the distribution of microglia within the developing forebrain.
Authors addressed the question 'what, if anything, is rodent prefrontal cortex?' by carrying out a survey of prefrontal cortex researchers and uncovered points of agreement as well as differences in regard to what brain areas constitute "prefrontal cortex" in rodents."
Authors show that axons of inhibitory neurons have distinctive structural and molecular features that contrast with those of the majority of myelinated excitatory axons in human neocortex.
Editor's Pick: ieAstrocytes: Newly Identified Functionally Active Astrocyte Population in a Mouse Model of Multiple Sclerosis
Authors functionally defined immediate-early astrocytes (ieAstrocytes) as an in vivo astrocyte population, modulated by S1P signaling, in a mouse model of multiple sclerosis.
A new study shows that advillin expression is NOT limited to sensory neurons in postnatal and adult mouse
Authors established a novel, automated live-cell imaging method to identify morphological changes in individual, dying human motor neurons.