Editor’s Pick: Exploring a Circuit That Promotes Wakefulness

The circuitry governing the wake–sleep cycle is remarkably complex, involving numerous parallel pathways. This study highlights a new wake-promoting circuit within the histaminergic system, a component whose role is frequently overlooked. Khouma et al. demonstrate that galanin, a neuropeptide released by sleep-active hypothalamic neurons, directly inhibits these histaminergic neurons to regulate arousal.

— Adrien Peyrache, Reviewing Editor

Read the full article:

Galanin inhibits wake-active histaminergic neurons via galanin receptor 1
Axelle Khouma, Albane Chabot-Chartier, Julie Plamondon, Alexandre Caron, and Natalie Jane Michael