Development

Drs. Alexandra Castillo-Ruiz and Nancy Forger sitting in their lab.
By Rosalind S.E. Carney, DPhil
June 11, 2020

Alexandra Castillo-Ruiz and Nancy Forger tell the story about their eNeuro paper that sheds light on the long-standing question of what controls the timing and magnitude of developmental neuronal cell death.

Authors demonstrate that ApoE deficiency and the ApoE4 human isoform both impair hippocampal neurogenesis in adult mice and give insight into how ApoE may influence hippocampal-related neurological diseases.
By David Graykowski
April 9, 2020

Authors demonstrate that ApoE deficiency and the ApoE4 human isoform both impair hippocampal neurogenesis in adult mice and give insight into how ApoE may influence hippocampal-related neurological diseases.

Authors describe the in vivo behavior of mitochondria at the growth cone of elongating retinal axons in zebrafish.
By Rosalind S.E. Carney, DPhil
February 6, 2020

Authors describe the in vivo behavior of mitochondria at the growth cone of elongating retinal axons in zebrafish.

Authors show interneuron defects in a new mouse model of premature birth that combines prenatal inflammatory and postnatal hypoxic insults.
By Sarah Santiago, PhD
August 15, 2019

Authors show interneuron defects in a new mouse model of premature birth that combines prenatal inflammatory and postnatal hypoxic insults.

Authors identify capsaicin receptor TRPV1 as a key regulator of Ca2+ entry into axoplasm that is required for developmental degeneration modeled by NGF withdrawal from sensory neurons of the dorsal root ganglion in vitro.
By Jeffery L. Twiss, M.D., Ph.D.
March 7, 2019

Authors identify capsaicin receptor TRPV1 as a key regulator of Ca2+ entry into axoplasm that is required for developmental degeneration modeled by NGF withdrawal from sensory neurons of the dorsal root ganglion in vitro.