Authors highlight a deficit in motor skill consolidation-dependent synaptic plasticity at motor cortex to dorsal striatum synapses that represents an early biomarker for Huntington’s Disease in mice.
This image shows MAP2+ neurites from cultured immature cortical neurons extending into a stripe of chondroitin sulfate proteoglycans (CSPGs) treated with chondroitinase ABC, an enzyme that abolishes CSPGs
Authors demonstrate that epidermal growth factor receptor antagonism not only blocks morphine tolerance but also restores the effectiveness of opioids against neuropathic pain.
See the most-shared articles of July/August 2020; Volume 7, Issue 4
Authors highlight TrkB-dependent molecular pathways as critical for the maturation of inhibitory interneurons and support the hypothesis that loss of BDNF signaling in cortistatin interneurons leads to altered excitatory/inhibitory balance.
Authors show neuronal subpopulation and sex differences in the biophysical signatures of developmentally defined medial amygdala output neurons.
Authors developed the open-source ToneBox tool, which allows both novice and expert behaviorists to automatically test hundreds of mice simultaneously on different behavioral tasks.
Parley Belsey and Eric Yttri tell the story about how they created a highly customizable, low cost and reproducible open-source behavior training platform for studying motor control, decision-making, and reaching reaction time in rodents.
See the most-shared articles of May/June 2020; Volume 7, Issue 3
Authors report a viable chaperone-based strategy for reversing the synaptic vesicle trafficking defects associated with excess α-synuclein, which may be of value for improving synaptic function in Parkinson’s disease and other synucleinopathies.