This image shows an immunostained whole-mount preparation of a mouse cochlea.

Authors highlight a deficit in motor skill consolidation-dependent synaptic plasticity at motor cortex to dorsal striatum synapses that represents an early biomarker for Huntington’s Disease in mice.

This image shows MAP2+ neurites from cultured immature cortical neurons extending into a stripe of chondroitin sulfate proteoglycans (CSPGs) treated with chondroitinase ABC, an enzyme that abolishes CSPGs

Reginald Cannady and Sudarat Nimitvilai-Roberts tell the story about their co-first author paper about time-dependent changes in cellular excitability of neurons in the prefrontal cortex following chronic voluntary ethanol drinking in mice.

Authors demonstrate that epidermal growth factor receptor antagonism not only blocks morphine tolerance but also restores the effectiveness of opioids against neuropathic pain.

See the most-shared articles of July/August 2020; Volume 7, Issue 4

An image of blood vessels in a region of the parietal cortex of a mouse with laminin, pericytes, and cell nuclei visible.

Authors highlight TrkB-dependent molecular pathways as critical for the maturation of inhibitory interneurons and support the hypothesis that loss of BDNF signaling in cortistatin interneurons leads to altered excitatory/inhibitory balance.

Authors show neuronal subpopulation and sex differences in the biophysical signatures of developmentally defined medial amygdala output neurons.

Authors developed the open-source ToneBox tool, which allows both novice and expert behaviorists to automatically test hundreds of mice simultaneously on different behavioral tasks.