Disorders of the Nervous System
Authors show that blocking endogenous Bone Morphogenetic Protein 4 signaling via a selective pharmacological approach promotes oligodendroglial differentiation and increases the rate of remyelination after a central demyelinating insult in vivo.
Authors provide the first functional description of the emergence of neocortical fast ripples in hippocampal epilepsy and show that cross-frequency coupling might be a fundamental mechanism underlying the spreading of epileptic activity.
Authors used well-established seizure protocols and fast confocal imaging of genetically encoded calcium indicator-expressing zebrafish to investigate epileptic network properties at brain-wide and single-cell levels.
Authors show that the same stress can elicit divergent morphological effects in astrocytes in the hippocampus versus the amygdala.
Authors found that experimentally induced stroke causes a secondary wave of brain tissue inflammation that shares some molecular and morphological characteristics with atherosclerosis.
Authors demonstrate that capsaicin, a TRPV1 agonist, activates a pro-axon growth program, suggesting an approach for enhancing axon regeneration in selective populations of neurons.
Authors functionally defined immediate-early astrocytes (ieAstrocytes) as an in vivo astrocyte population, modulated by S1P signaling, in a mouse model of multiple sclerosis.