Neuroscience Research

Figure 1. High-speed confocal imaging and LFP recording in the forebrain of GCaMP-expressing zebrafish larvae. (A) Timeline of confocal imaging and LFP recording relative to immobilization of larvae in agar and exposure to convulsant drugs. High-speed confocal recordings were obtained ∼40 minutes after drug exposure, with 5× and 20× objectives used for whole-brain and single neuron imaging, respectively. (B) Simultaneous high-speed confocal imaging and LFP recording in agar-embedded larvae. (C) Schematic illustration depicting sub-regions of the larval zebrafish brain. (D) Representative 5× image of Tg(neurod1:GCaMP6f) zebrafish at 5–6 days postfertilization. (Adapted from Figure 1 in Liu & Baraban et al., 2019.)
By Rosalind S.E. Carney, DPhil
May 9, 2019

Authors used well-established seizure protocols and fast confocal imaging of genetically encoded calcium indicator-expressing zebrafish to investigate epileptic network properties at brain-wide and single-cell levels.

See the most shared articles of March/April 2019; Volume 6,Issue 2
By SfN Staff
May 9, 2019

See the most shared articles of March/April 2019; Volume 6,Issue 2

Dr. Laura Blair tells the story about her first-author eNeuro paper that showed that mice with high expression levels of the FK506-binding protein FKBP51 have altered reversal learning and memory, which may be through direct regulation of neuronal activity by regulating AMPA receptors.
By Rosalind S.E. Carney, DPhil
April 25, 2019

Dr. Laura Blair tells the story about her first-author eNeuro paper that showed that mice with high expression levels of the FK506-binding protein FKBP51 have altered reversal learning and memory, which may be through direct regulation of neuronal activity by regulating AMPA receptors.

Authors show that excitation and inhibition of pyramidal neurons in different basolateral amygdala subdivisions promote auditory fear memory formation.
By Rosalind S.E. Carney, DPhil
April 18, 2019

Authors show that excitation and inhibition of pyramidal neurons in different basolateral amygdala subdivisions promote auditory fear memory formation.

Authors used a novel method to show that selectively activating cholecystokinin-expressing GABAergic neurons subtly affects emotional behavior but surprisingly enhances multiple memory and cognitive processes.
By Thomas J. McHugh, PhD
April 4, 2019

Authors used a novel method to show that selectively activating cholecystokinin-expressing GABAergic neurons subtly affects emotional behavior but surprisingly enhances multiple memory and cognitive processes.

Authors show that the same stress can elicit divergent morphological effects in astrocytes in the hippocampus versus the amygdala.
By Abha Karki Rajbhandari, PhD
March 28, 2019

Authors show that the same stress can elicit divergent morphological effects in astrocytes in the hippocampus versus the amygdala.

Authors show that the memory of eating a recent meal likely inhibits subsequent food consumption.
By Benjamin M. Seitz
March 21, 2019

Authors show that the memory of eating a recent meal likely inhibits subsequent food consumption.

By SfN Staff
March 14, 2019

See the most shared articles of January/February 2019; Volume 6,Issue 1

Authors identify capsaicin receptor TRPV1 as a key regulator of Ca2+ entry into axoplasm that is required for developmental degeneration modeled by NGF withdrawal from sensory neurons of the dorsal root ganglion in vitro.
By Jeffery L. Twiss, M.D., Ph.D.
March 7, 2019

Authors identify capsaicin receptor TRPV1 as a key regulator of Ca2+ entry into axoplasm that is required for developmental degeneration modeled by NGF withdrawal from sensory neurons of the dorsal root ganglion in vitro.

Authors found that experimentally induced stroke causes a secondary wave of brain tissue inflammation that shares some molecular and morphological characteristics with atherosclerosis.
By Matthew Davidson, PhD
February 14, 2019

Authors found that experimentally induced stroke causes a secondary wave of brain tissue inflammation that shares some molecular and morphological characteristics with atherosclerosis.