An automated analysis approach to reduce the heterogeneity of dendritic spine morphology could enhance reproducibility in neurological disorders with defective synaptic transmission.
Authors targeted the microglia-specific Tmem119 gene to generate two novel mouse models that can be used to visualize and control reporter protein expression in microglia with improved distinction from closely related cell types.
Authors suggest that blue light stimulation is ill-suited to long-term optogenetic experiments, especially those that measure transcription.
This research offers an important contribution to the knowledge of molecular mechanism of worm learning and sensory integration that may be applicable to learning in many organisms.
Authors show that key features of the microglial activation pattern observed after status epilepticus may not be related to the epileptogenic process.
Authors show interneuron defects in a new mouse model of premature birth that combines prenatal inflammatory and postnatal hypoxic insults.
Authors show that one olfactory cortical structure, the olfactory tubercle, is unique among olfactory cortices in that it lacks feedback projections to the olfactory bulb.
Authors show that blocking endogenous Bone Morphogenetic Protein 4 signaling via a selective pharmacological approach promotes oligodendroglial differentiation and increases the rate of remyelination after a central demyelinating insult in vivo.
Authors show that the same stress can elicit divergent morphological effects in astrocytes in the hippocampus versus the amygdala.
Authors show that the memory of eating a recent meal likely inhibits subsequent food consumption.